Scrub Typhus Pediatric Immunology Study

Inclusion Criteria: Scrub Typhus Patients (STP) Cohort inclusion criteria * Age \>6 months to ≤18 years (STP consist of pediatrics only) * Scrub Typhus Rapid test positivity (SDm Standard Diagnostics RDT, Korea) * O. tsutsugamushi PCR-positivity (if PCR capability is available by the start of the study) * Fever in ≤ 14 days of presentation to Hospital * Willingness to participate in the study and written informed assent previously obtained from the patient, and written informed consent obtained from the patient's parent(s), guardian(s) or representative(s) Scrub Typhus Exposed (STE) Cohort inclusion criteria * Age \>6 months to ≤18 years and age \>18 years (STE consist of paediatrics and adult ) * Historical diagnosis of scrub typhus, as defined by rapid diagnostic test, serology and/or PCR positivity (more than 2 years ago), or living in an endemic area with high risk of previous exposure. * Currently well and healthy * Willingness to participate in the study and written informed assent previously obtained from the patient, and written informed consent obtained from the patient's parent(s), guardian(s) or representative(s) Scrub Typhus Healthy (STH) Cohorts inclusion criteria * Age \>18 years (STH consist of adults only) * Currently well, no medical problems requiring hospital specialist supervision * Willingness to participate in the study and written, informed consent previously obtained * Residing in Bangkok for at least the 2 past recent years Exclusion Criteria: …