CompletedNot Applicable

Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee

United States15 participantsStarted 2015-03

Plain-language summary

This study plans to learn more about ways to treat a joint problem in the knee called Juvenile Osteochondritis Dissecans (OCD). The goal of this study is to see if injecting platelet-rich plasma (PRP) into the knee can help knee cartilage heal faster, and will try to determine whether the injections lead to improvements in pain, performance of activities of daily living, improvements is sports activities and overall function and symptoms reduction. The investigators will compare PRP treatment to conservative therapy.

Who can participate

Age range10 Years – 17 Years

SexALL

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Inclusion criteria

✓. Male or female age 10 - 17 inclusive with open physis confirmed by MRI
✓. Documented symptomatic stable juvenile osteochondritis dissecans of the knee based on MRI without changes of osteoarthritis and no prior history of knee surgery.
✓. The patient must be able to hold still without sedation for approximately 1 hour and must pass MRI screening evaluation for retained metal.
✓. Patients with Di Paola stage 1 or 2 lesions

Exclusion criteria

✕. Patients with polyarticular disease.
✕. Patients with blood disorders (Blood disorders (thrombopathy, thrombocytopenia, anemia with hemoglobin \<9g/dL). Only those patients with a positive history of blood disorders will have a Complete Blood Count (CBC) performed a week prior to inclusion in the study.
✕. Patients who had intra-articular treatment with steroids within 3 months
✕. Patients who are pregnant or nursing at the time of consent.
✕. Patients with inflammatory arthritic conditions (e.g. rheumatoid arthritis)
✕. Non-English speaking patients. (Scores used for evaluation have not been validated in Spanish)
✕. Patients who had previous knee surgery
✕. Additional disabilities in any of the lower limbs that would interfere with any of the clinical assessments.

What they're measuring

Greater Cartilage Healing Measured by Glycosaminoglycan Content on dGEMRIC MRI

Timeframe: 6 months

Trial details

NCT IDNCT02397278

SponsorUniversity of Colorado, Denver

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-01-08

Results submitted2021-07-14

View on ClinicalTrials.gov More Osteochondritis Dissecans trials