CompletedNot Applicable

Influence of Patient/Ventilador Decoupling in Neurocognitive and Psychopathological Sequelae in ICU Patients

Spain156 participantsStarted 2015-06

Plain-language summary

Mechanical ventilation (MV) is a vital support tool for critically ill patients. However, it may present several adverse effects, such as the development of cognitive and psychopathological alterations. Patient-ventilator asynchronies occur frequently since the beginning of the MV. These asynchronies are associated with poor clinical outcome and could be responsible for the neuronal changes causing these alterations. The objective of this project is to analyze the influence of patient-ventilation asynchronies in the development of long-term cognitive/psychopathological impairments and to explore the molecular mechanisms that could explain of these alterations. An exploratory, observational, multicenter, non-interventionist study will be performed in 150 ICU patients. The continuous recording of asynchronies and other clinical variables during ICU stay and the results of neuropsychological assessments will enable to identify clinical clusters associated with cognitive/psychopathological impairments.

Who can participate

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Aged 18 to 80 years old. * No neurological disease * No evidence of COPD. * Patients within the following 24 hours at endotracheal intubation and who are clinically expected to receive \> 72 hours of mechanical ventilation Exclusion Criteria: * No authorization of the family or patient inclusion. * Age outside the limits. * Patients with prior neurological disease or focal brain damage prior to admission to the ICU * Patients with serious psychiatric illness or mental retardation. * Time monitoring of asynchrony \< 80% of the total duration of mechanical ventilation. * Patients who develop secondary complications (infections, stroke, brain damage or structural TC acquired) after discharge from ICU (during hospital stay) that could compromise the results of neuropsychological assessment. * Patients with moderate to severe cognitive impairment previous to ICU stay (Short form IQCODE \> 57 score)

What they're measuring

Short-term neurocognitive alterations

Timeframe: 1month after ICU discharge

Trial details

NCT IDNCT02390024

SponsorCorporacion Parc Tauli

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-03