CompletedNot Applicable

Pilot Study of Coil Arrays in Patients With Advanced Solid Tumor Malignancies

United States7 participantsStarted 2015-01-08

Plain-language summary

This is a single center pilot study testing the use of novel coil arrays with MR liver imaging. In part A of the study, up to 30 healthy volunteers will be scanned, with iterative adjustment of coil array geometry and design to optimize imaging characterstics. In Part B of the study, 40 patients with advanced solid tumors and at least one liver metastasis measuring \> 1.5 cm in diameter on standard anatomic scans will undergo MR liver imaging with the newly designed coil array, with the use of gadolinium contrast. Patients with liver tumors will have the option of undergoing a second MR liver scan during the course of subsequent systemic therapy.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria (Part B only - Patients with advanced solid tumor): * Advanced solid tumor malignancy and the presence of at least one liver metastasis measuring \> 1.5 cm in longest diameter in axial dimension on standard anatomic imaging Exclusion Criteria (Part B only): * Contra-indication to gadolinium contrast (e.g. chronic renal disease, prior allergic reaction) for patient studies Exclusion Criteria (Part A \[Healthy Volunteers\] and Part B): * Contra-indication to MRI (e.g. pacemaker, severe claustrophobia, suspected presence of MR-Unsafe surgical implants or shrapnel)

What they're measuring

Spatial Resolution

Timeframe: Day 1

Scan coverage

Timeframe: Day 1

Mean contrast-to-noise ratio

Timeframe: Day 1

Trial details

NCT IDNCT02390011

SponsorUniversity of California, San Francisco

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2015-05-16

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