Genetics of Primary Ciliary Dyskinesia

Inclusion Criteria: * Any patient who has ≥ 2 clinical features (+/- lab) characteristic of PCD, including: * Neonatal respiratory distress after term (or near-term) birth * and/or laterality defect ( situs inversus or heterotaxy) * and/or daily wet cough before 6 months of age * and/or middle ear disease * and/or chronic nasal congestion before 6 months of age * and/or bronchiectasis * and/or male infertility due to sperm tail dysfunction * and/or low nasal nitric oxide levels (\<77 nanoliters/minute) * and/or defective ciliary ultrastructure Exclusion Criteria: * Known diagnosis of cystic fibrosis with classic clinical presentation and elevated sweat chloride levels and/or two known disease-causing Cystic Fibrosis transmembrane conductance regulator (CFTR) mutations, or documented primary or acquired immunodeficiency. * Known explanation for bronchiectasis (and other clinical features), such as α1-antitrypsin deficiency (ZZ or ZS), inflammatory bowel disease or rheumatoid arthritis. * Any patient who is unwilling or unable to provide consent or to comply with the testing required in this protocol A participant should not be in the study if they have not had a standard clinical evaluation to address other potential causes of chronic oto-sino- pulmonary disease.