Real-Time Contrast-Enhanced Ultrasonography and Shear Wave Elastography in Predicting Treatment Response in Patients With Soft Tissue Sarcoma

Inclusion Criteria: * Patients with biopsy and/or conventional imaging (CT/MRI) proven STS or bone sarcoma with a measurable soft tissue component; these include patients with extremity, retroperitoneal, chest wall, or head and neck primary sarcomas * Patients who are potential candidates to receive neoadjuvant therapy with either chemotherapy alone, radiation alone, immunotherapy alone or combined treatment with any of these modalities. If on therapy, patients in whom a new treatment protocol or modality is being considered. * Patients competent to sign study specific informed consent * Patients willing to comply with protocol requirements Exclusion Criteria: * Patients who are pregnant * Patients who have a known cardiac shunt or pulmonary hypertension * Patients with any known hypersensitivity to perflutren agent * Patients who cannot consent for themselves