WithdrawnNot Applicable

Postprandial Lipidemia After a Meal With Different Types of Fat, Estrogen Treatment, Age and Gender in Healthy Subjects

Stopped: Never started the inclusion

Denmark0Started 2019-08-10

Plain-language summary

The study examines the effect of hormone replacement in postmenopausal women compared to men, 55 years of age, and in the elderly without hormone replacement of both sexes. The lipid and glucose metabolism is evaluated during treatment and placebo with a meal with mashed potatoes and different types of fat. Glucose, insulin, triglyceride, total cholesterol, LDL and HDL cholesterol, free fatty acids and coagulation parameters are measured. During menopause the women reduce their levels of estrogen and their risk of cardiovascular disease rises to the men's level. This effect on mortality and morbidity can probably be reduced by hormone therapy.

Who can participate

Age range45 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Men, age 45-55 * Men age 65-80 * Women age 45-55: The menopausal women's follicle stimulating hormone and luteinizing hormone levels should be above 40 nmol/l * Women age 65-80 Exclusion Criteria: * hypercholesterolemia, * hypertension, * substance abuse or alcohol abuse * recognized renal, hepatic, cardiac and metabolic disorders, * thromboembolic diseases, * active cancer of the uterus or breast or * other hormone replacement therapy. * If pronounced side effects of hormone treatment, the subject is omitted from the trial

What they're measuring

Postprandial lipidemia

Timeframe: Three months of estrogen treatment

Trial details

NCT IDNCT02383823

SponsorHerning Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-12-10

View on ClinicalTrials.gov More Menopause trials