CompletedNot Applicable

Effects of Deer Bone Extract NS on Improvement in Cognitive-Bio-Markers of Cognitive Functions

South Korea75 participantsStarted 2013-07

Plain-language summary

This study aims to elucidate the effects of deer bone extract NS on cognitive function improvement and its safety in healthy adults aged 40 to 65 years who report decline in subjective cognitive functions using multimodal neuroimaging and neurocognitive assessments.

Who can participate

Age range

40 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age between 40 and 65 years old, * Global Deterioration Scale score (GDS) of 2 * High school or higher levels of education. Exclusion Criteria: * Current pregnancy or breast-feeding * Evidence of neurologic or medical conditions * Axis I diagnosis when assessed by the board certified psychiatrist using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorder, 4th edition (DSM-IV)(SCID-IV), * One or more major depressive episode during last 12 months * Mini-mental status examination score of 24 or less * Clinical Dementia Rating score of 0.5 or more suggesting cognitive impairment beyond self-perceived subjective deficits * Intelligence quotient less than 70 * Any history of head trauma involving loss of consciousness or seizure * Contraindications to magnetic resonance imaging (MRI) * Use of psychotropics in last 3 months * Use of oral contraceptive medication * Participation in other clinical trials during the study period that might affect the outcome of the present study.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Changes from baseline in neurocognitive function

Timeframe: Baseline, 8th week

Changes from baseline in brain structure analyzed using the computational approach

Timeframe: Baseline, 8th week

Changes from baseline in brain function analyzed using the computational approach

Timeframe: Baseline, 8th week

Changes from baseline in brain biochemical metabolism analyzed using the computational approach

Timeframe: Baseline, 8th week

Trial details

NCT IDNCT02379481

SponsorEwha Womans University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-06

View on ClinicalTrials.gov More Healthy Adults With Subjective Memory Complaints trials

Who can participate

Age range

40 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Changes from baseline in neurocognitive function

Timeframe: Baseline, 8th week

Changes from baseline in brain structure analyzed using the computational approach

Timeframe: Baseline, 8th week

Changes from baseline in brain function analyzed using the computational approach

Timeframe: Baseline, 8th week

Changes from baseline in brain biochemical metabolism analyzed using the computational approach

Timeframe: Baseline, 8th week