TerminatedNot Applicable

Bisphenol A Exposure, Ovarian Function and Assisted Reproductive Technology Outcome.

Stopped: Recruitment target not obtained

France350 participantsStarted 2014-10

Plain-language summary

Our goal is to prospect the relationships between Bisphenol A (BPA) exposure (measured as its free and conjugated forms in blood and urine) and embryo implantation rate (measured as the ratio between the number of gestational sacs and the number of transferred embryos) after assisted reproductive technology. In order to reduce the confusion factors, the population study is limited to young women (aged 28 to 34), with regular menstrual cycles and without any medical event that could affect the implantation process

Who can participate

Age range28 Years – 34 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Couples attending an IVF or ICSI attempt whose woman is aged 28 ans to 34 at inclusion time * Regular menstrual cycles (between 27 and 33 days) * 1st or 2nd IVF or ICSI attempt with an embryo transfer at D2 or D3 Exclusion Criteria: * couple already included in the study * ovarian surgery history * uterine (malformation, diethylstilbestrol (DES) syndrome, adenomyosis…) or systemic pathology that can affect implantation (thrombophilia, antiphospholipids syndrome…) * chemotherapy history for the woman * any endocrinopathy (except dysthyroid) in the woman * any pelvic surgery for the woman in the 3 months preceding inclusion * endometriosis * ICSI with testicular sperm * Positive viral load for HIV, hepatitis C virus or hepatitis B virus (HCV or HBV) during the year preceding inclusion in one or both members of the couple

What they're measuring

embryo implantation rate

Timeframe: 6 weeks after implantation

Trial details

NCT IDNCT02377219

SponsorUniversity Hospital, Toulouse

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-07