CompletedNot Applicable

Effect of Childhood Radioiodine Therapy on Salivary Function

United States70 participantsStarted 2014-09

Plain-language summary

Radioiodine (I-131) therapy for thyroid disease is known to decrease salivary function in adult patients. The impact of pediatric I-131 exposure on salivary function is unknown. The investigators goals are to answer this question by measuring salivary gland function before and after I-131 administration in children who receive radioiodine therapy at our hospital for thyroid disease.

Who can participate

Age range3 Years – 55 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients who have been treated with radioiodine therapy * Patients who have never received radioiodine therapy (negative control group) Exclusion Criteria: * Non-English speaking subjects will be excluded due to our lack of translation support resources at this time. Of note, participation in our study cannot benefit participants in any way.

What they're measuring

Salivary function (MST value)

Timeframe: 0 to 50 years after radioiodine treatment

Responses to Dry Mouth Questionnaire

Timeframe: At time of visit up to 4 months thereafter.

Trial details

NCT IDNCT02375451

SponsorBoston Children's Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2016-09

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