TerminatedPhase 2

Topical Use of Vancomycin in Reducing Sternal Wound Infection in Cardiac Surgery (SWI Trial)

Stopped: the preliminary analysis of study result did not show significant benefit that was anticipate

1,037 participantsStarted 2015-03

Plain-language summary

The purpose of this research is to determine if using the antibiotic vancomycin as a preventative topical (on the surface of the skin) treatment during open-heart surgery will reduce the risk of developing a sternal wound infection.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Able to sign Informed Consent and Release of Medical Information Form * Age ≥ 18 years * Undergoing cardiac surgery with complete sternotomy (including re-operations) Exclusion Criteria: * Evidence of active infection (any culture positive or blood positive infection) * Undergoing organ transplantation * Patients with known hypersensitivity to vancomycin * Pregnant or nursing women * Mental impairment or other conditions that may not allow participant to understand the nature, significance, and scope of study

What they're measuring

Number of Sternal Wound Infections

Timeframe: 3 months postoperative

Trial details

NCT IDNCT02374853

SponsorUniversity of Alberta

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-04

Results submitted2022-08-17

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