CompletedNot Applicable

Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects

United States398 participantsStarted 2015-04

Plain-language summary

This study is being done to learn more about normal thinking and behavior, mild thinking and behavior problems, Frontotemporal Dementia and other forms of dementia in families in which one or more relatives have a mutation associated with Frontotemporal Dementia.

Who can participate

Age range18 Years – 90 Years

SexALL

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Inclusion criteria

✓. Must be a member of family with a known mutation in one of the three major FTLD related genes: MAPT, PGRN, or C9ORF72.
✓. At least 18 years of age.
✓. The predominant phenotype in the kindred must be cognitive/behavioral (ie, kindreds in whom parkinsonism or ALS is the predominant clinical phenotype among affected relatives may be excluded)
✓. Have a reliable informant who personally speaks with or sees that subject at least weekly.
✓. Subject is sufficiently fluent in English to complete all measures
✓. Subject must be willing and able to consent to the protocol and undergo yearly evaluations over 3 years.
✓. Subject must be willing and able to undergo neuropsychological testing (at least at baseline visit).
✓. Subject must have no contraindication to MRI imaging.

Exclusion criteria

✕. Known presence of a structural brain lesion (e.g. tumor, cortical infarct).
✕. Presence of another neurologic disorder which could impact findings (eg, multiple sclerosis).
✕. Subject is unwilling to return for follow-up yearly, undergo neuropsychological testing and MR imaging.
✕. Subject has no reliable informant.

What they're measuring

Rate of decline in traditional measures of clinical (neuropsychological and behavioral composites) function and cortical volume on structural MRI in the symptomatic phase of familial FTD

Timeframe: 5 years

Trial details

NCT IDNCT02372773

SponsorMayo Clinic

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-06-30

View on ClinicalTrials.gov More Familial Frontotemporal Dementia trials