CompletedPhase 2/3

Simvastatin and Metformin in Chronic Periodontitis

98 participantsStarted 2013-12

Plain-language summary

This randomized controlled clinical trial compares efficacy of 1.2% simvastatin with 1% metformin in chronic periodontitis subjects.

Who can participate

Age range30 Years – 50 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Systemically healthy subjects * Pocket depth ≥ 5 mm * Clinical attachment level ≥ 4 mm and vertical bone loss ≥ 3 mm on intraoral periapical radiographs, with no history of periodontal therapy in the last 6 months Exclusion Criteria: * Subjects allergic to MF or SMV * Those on systemic MF or SMV therapy * Subjects with aggressive periodontitis * Immunocompromised subjects * Use of tobacco in any form, alcoholics * Lactating and pregnant females

What they're measuring

Change in defect depth reduction from baseline to 6 months and from baseline to 9 months

Timeframe: Baseline to 6 months and Baseline to 9 months

Trial details

NCT IDNCT02372656

SponsorGovernment Dental College and Research Institute, Bangalore

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-08

View on ClinicalTrials.gov More Chronic Periodontitis trials