A Multicenter, Randomized, Controlled Study to Assess Mitral vAlve reconsTrucTion for advancEd Insufficiency of Functional or iscHemic ORigiN

Inclusion Criteria: * Clinically significant mitral regurgitation of primarily functional pathology * Left Ventricular Ejection Fraction (LVEF) ≥20% determined by echocardiography * High surgical risk as determined by Heart Team consensus * Documented New York Heart Association Class II to Class IV heart failure, despite optimal standard of care therapy * Written informed consent in accordance with Good Clinical Practice (GCP) and local legislation Exclusion Criteria: * Echocardiographic evaluation not available or not suitable for analysis at baseline * Severe tricuspid regurgitation according to current guidelines5 * Other severe valve disorders requiring intervention according to current * Coronary revascularization or cardiac resynchronization (CRT) device implantation within 1 month before the procedure * Patient not amenable for mitral valve surgery/ percutaneous mitral valve reconstruction as judged by Heart Team * Key information from patients (e.g. NYHA, MR grade) not available