RecruitingNot Applicable

Peripheral Blood Flow Responses to Electromagnetic Energy

United States40 participantsStarted 2014-11

Plain-language summary

This study evaluates 670 nm energy in the form of red light to stimulate blood flow changes in healthy adults. All participants will receive red light to their leg. They will also receive a continuous infusion of Definity (octafluoropropane) ultrasound contrast.

Who can participate

Age range

18 Years – 59 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Participants will be healthy subjects over the age of 18. * Men and women will be recruited for participation. * All ethnicities will be included in this study. Exclusion Criteria: Exclusionary criteria include: * age under 18 years and those over 60 years of age, * those who are unable to understand the consent process, * those who cannot read or speak English, * a history of cancer, * peripheral artery disease, * diabetes mellitus, * active pregnancy, * hypersensitivity to perflutren contrast agents, * pulmonary hypertension, * chronic kidney disease, * active tobacco or drug use, * blood pressure over 160/90, BMI\>30, * sickle cell disease, or * history of intracardiac shunt. Additional exclusion criteria include: * a history of coronary artery disease, * heart failure, * the presence of an implanted defibrillator or pacemaker, * a history of heart murmur or rhythm disorder (atrial fibrillation, atrial tachycardia, or ventricular tachycardia), * neurological diseases such as stroke, and * any uncontrolled medical conditions.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in blood flow (using octafluoropropane infusion and ultrasound)

Timeframe: 10 minutes

Trial details

NCT IDNCT02370199

SponsorUniversity of Alabama at Birmingham

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12-31

Contact for this trial

Nicole L Lohr, MD, PhD

205-996-3504 nlohr@uabmc.edu

View on ClinicalTrials.gov More Exposure to Man-made Visible Light trials

Who can participate

Age range

18 Years – 59 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.