WithdrawnPhase 2

Does Terlipressin Improve Renal Outcome After Liver Surgery

Stopped: no focus on this topic

Switzerland0Started 2020-01

Plain-language summary

The investigators aim to address whether terlipressin improves the renal outcome after liver surgery. Therefore the investigators are planning to conduct a double-blinded randomized control trial. The investigators will randomize patients undergoing any kind of liver surgery and being at increased moderate to high risk for post-operative acute renal failure into a control group receiving post- operative a placebo or into a group receiving post-operatively terlipressin in combination with human albumin.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * \>=12% risk for post-operative ARF on our recently developed and validated prediction score for ARF after liver surgery, patients will need five points or more in the pre-operative assessment of the predictors to be enrolled in the trial Exclusion Criteria: * \< 18 years * liver cirrhosis * coronary insufficiency with ST-elevation or ST-depression in the - - intra-operative ECG as signs of an acute coronary syndrome * pregnancy and breast feed

What they're measuring

serum creatinine peak level within 48 hours post-operative

Timeframe: within 48 hours post-operative

Trial details

NCT IDNCT02368249

SponsorUniversity of Zurich

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-02

View on ClinicalTrials.gov More Kidney Failure trials