CompletedNot Applicable

Effect of Hypothyroidism on Brown Adipose Tissue

Switzerland42 participantsStarted 2015-04

Plain-language summary

The investigators aim to study whether hypothyroidism negatively affects Brown adipose tissue (BAT) function in humans and whether BAT function can be restored to normal by thyroid hormone supplementation.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * informed consent * Serum thyroid-stimulating hormone (TSH) \> 4.5 milli-International unit (mIU)/l * body mass index (weight/height(m)²) 17.5 to 30 kg/m² Exclusion Criteria: * known concomitant disease influencing thyroid hormone metabolism * chronic heart failure * liver cirrhosis * severe kidney failure * metastasized cancer, except for thyroid cancer * known hypersensitivity to cold, e.g. primary or secondary Raynaud's syndrome * abuse of alcohol or illicit drugs * Women who are pregnant or breast feeding * Intention to become pregnant during the course of the study * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant * Participation in another study with investigational drug within the 30 days preceding and during the present study * Previous enrolment into the current study

What they're measuring

difference in cold induced thermogenesis between baseline and restoration of euthyroidism, assessed as the increase in resting energy expenditure after a mild cold stimulus determined by indirect calorimetry

Timeframe: before and after 3 months after restoration of euthyroidism

Trial details

NCT IDNCT02364102

SponsorUniversity Hospital, Basel, Switzerland

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2017-08

View on ClinicalTrials.gov More Hypothyroidism trials