The Comparison of Stress Response to Rapid Opioid Detoxification Applying Different Methods of Op… (NCT02362256) | Clinical Trial Compass
CompletedNot Applicable
The Comparison of Stress Response to Rapid Opioid Detoxification Applying Different Methods of Opioid Antagonism
Lithuania60 participantsStarted 2014-05
Plain-language summary
The aim of this study is to investigate which method of naltrexone induction during rapid opioid detoxification causes stronger stress response and has a higher influence on opioid abstinence caused by opioid induction.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Opiate addiction
* Use of short-acting opiate (morphine or heroine)
* Age \> 18 years
* Length of opiate addiction \> 1 year
* Patient can make a decision for detoxification and has a capacity to consent for procedure
* Written consent for procedure
Exclusion Criteria:
* Polyvalent addiction
* Pregnancy or breast feeding
* Cardiovascular pathology
* Acute or chronic kidney disease
* Decompensated liver pathology (jaundice, ascites, hepatic encephalopathy)
* Infective complications of opiate addiction (pneumonia, phlegmon, abscess, thombophlebitis, sepsis)
* Malnutrition (Nutritional risk screening 2002 score ≥3)
* Diabetes mellitus
* Previous history of psychosis
* Glasgow coma scale \< 15
* Abdominal surgical intervention during last 30 days
* Cumulative buprenorphine dose for stabilization \< 8 mg
* Positive test for psychoactive substances during treatment
* Refusal to participate in study at any point of it
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.