The Influence of Different Hydrocortisone Replacement Doses on the Partitioning and Flexibility of Ectopic Lipids in Patients With Corticotropic Hypopituitarism

Inclusion Criteria: * Written informed consent * Male and female patients * Corticotropic pituitary insufficiency * Capable to exercise during 120 minutes on a bicycle * Normal ECG during ergometry Exclusion Criteria * Concomitant medication with NSAID, anticoagulants, digoxin, salbutamol, anticonvulsants, cholinesterase inhibitor, pancuronium * Abnormal liver, renal or thyroid function, heart failure * Hemophilia * Diabetes mellitus * Severe dyslipidemia * Active neoplasia * Women who are pregnant or breast feeding * Intention to become pregnant during the course of the study * Lack of safe contraception * Known or suspected non-compliance * Drug or alcohol abuse * Inability to follow the procedures of the study * Participation in another study with investigational drug within the 30 days preceding and during the study * Previous enrolment into current study * Enrolment of the investigator, his/her family members, employees and other dependent persons * Inability to exercise * Contraindications to exposure to a 3 T magnetic field * Major depression, psychosis, claustrophobia