TerminatedNot Applicable

The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation in Poor Responders

Stopped: Many patients couldn't wait for DHEA treatment for three months.

China60 participantsStarted 2014-01-01

Plain-language summary

The supplementation of Dehydroepiandrosterone (DHEA) has been used in some centers for patients with previous poor ovarian reserve and response in an attempt to improve pregnancy outcomes. However, there still has controversy on the clinical effect on the 75mg/d for the use,especially in Asian people. Whether the double dosage of DHEA in patients with poor ovarian reserve and response in China can improve the IVF outcome with little side effect is unknown. The aim of this randomized controlled study is to compare the effect of a higher dose (150mg daily) and a standard dose (75mg daily) of DHEA on the number of oocytes obtained in poor ovarian responders. The effect of DHEA action on the cumulus cells will be examined.

Who can participate

Age range22 Years – 45 Years

SexFEMALE

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Inclusion criteria

✓. age\<45 years,
✓. subfertility \>1 year, and
✓. A previous POR (≤3 oocytes with a conventional stimulation protocol of at least 150 IU FSH per day); or
✓. An abnormal ovarian reserve test (i.e. AFC ≤5-7 follicles or AMH ≤0.5-1.1 ng/ml).

Exclusion criteria

✕. had a history of ovarian cystectomy or oophorectomy,
✕. had received cytotoxic chemotherapy,
✕. had received pelvic irradiation, or
✕. had a history of taking testosterone or DHEA supplementation

What they're measuring

The Number of Oocytes Obtained

Timeframe: After taking DHEA for 12 weeks

Trial details

NCT IDNCT02357472

SponsorShangHai Ji Ai Genetics & IVF Institute

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-12-31

Results submitted2016-08-10

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