Stopped: Lack of funding required to enroll target subject number
This study seeks to examine the effectiveness of training while in a hyperoxic-hyperbaric environment for exercise performance at altitude. Subjects will complete a short, high-intensity interval training (HIT) program inside the hyperbaric chamber.Before and after this training phase, all subjects will be tested for maximum aerobic capacity at a simulated high altitude of 15,000ft in a hypobaric chamber, as well as for molecular markers of mitochondrial oxidative capacity in a skeletal muscle biopsy. A group of individuals of similar characteristics completing this training program in a normoxic-normobaric environment will serve as a control.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Change in Maximum Aerobic Capacity (VO2max) From Baseline to Post-training (< 72 Hours )
Timeframe: Baseline and <72 hrs Post-training
Change in Ventilatory Threshold (VT) From Baseline to Post-training (<72 Hours)
Timeframe: Baseline and <72 hrs Post-training
Mitochondrial Mass Change
Timeframe: Baseline/24 hrs Post-training
Tfam Muscle Protein Content Change
Timeframe: Baseline/24 hrs Post-training
Pgc-1a Coactivator Muscle Protein Content Change
Timeframe: Baseline/24 hrs Post-training
COX-I Gene Expression Change
Timeframe: Baseline/24 hrs Post-training
Muscle Phenotype Change
Timeframe: Baseline/24 hrs Post-training