Stopped: Lack of funding required to enroll target subject number
This study seeks to examine the effectiveness of training while in a hyperoxic-hyperbaric environment for exercise performance at altitude. Subjects will complete a short, high-intensity interval training (HIT) program inside the hyperbaric chamber.Before and after this training phase, all subjects will be tested for maximum aerobic capacity at a simulated high altitude of 15,000ft in a hypobaric chamber, as well as for molecular markers of mitochondrial oxidative capacity in a skeletal muscle biopsy. A group of individuals of similar characteristics completing this training program in a normoxic-normobaric environment will serve as a control.
Age range
18 Years – 35 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Change in Maximum Aerobic Capacity (VO2max) From Baseline to Post-training (< 72 Hours )
Timeframe: Baseline and <72 hrs Post-training
Change in Ventilatory Threshold (VT) From Baseline to Post-training (<72 Hours)
Timeframe: Baseline and <72 hrs Post-training
Mitochondrial Mass Change
Timeframe: Baseline/24 hrs Post-training
Tfam Muscle Protein Content Change
Timeframe: Baseline/24 hrs Post-training
Pgc-1a Coactivator Muscle Protein Content Change
Timeframe: Baseline/24 hrs Post-training
COX-I Gene Expression Change
Timeframe: Baseline/24 hrs Post-training
Muscle Phenotype Change
Timeframe: Baseline/24 hrs Post-training