CompletedNot Applicable

Follicular Activation in Poor Responders

Spain34 participantsStarted 2014-11

Plain-language summary

This study aims to assess whether activation of primordial follicles through ovarian cortex fragmentation may increase the number of antral follicles present in the ovary of patients with diminished ovarian reserve. Secondary outcomes include number of oocytes retrieved and pregnancy rates after IVF. Hypothesis; Evaluate whether the proposed intervention increases the pool of antral follicles (potentially stimulable ones).

Who can participate

Age range18 Years – 40 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria (must meet one): * At least two episodes of poor ovarian response (≤ 3 oocytes retrieved with a standard protocol). * A previous IVF cycle with ≤ 3 oocytes (following a standard stimulation protocol) and presence of an abnormal ovarian reserve test (antral follicle count of ≤ 5 or antimüllerian hormone ≤ 5pm). Exclusion Criteria (must not meet any): * Patients under 18 or over 40 years. * Clinical signs of endometriosis. * Previous ovarian surgery. * Genital tract malformations. * Anovulatory patient (defined by the presence of irregular cycles and serum progesterone ≤ 10 ng / mL on cycle day 21). * Partner with severe male factor: severe oligoasthenozoospermia, oligoasthenoteratozoospermia and azoospermia. * All those patients who do not voluntarily give their express written consent.

What they're measuring

Number of Metaphase II (MII)

Timeframe: 36 hours after triggering

Trial details

NCT IDNCT02354963

SponsorCésar Díaz García

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-02

Results submitted2022-04-12

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