Effect of Neem Extract, Propylene Glycol and Salicylic Acid Combination in the Treatment of Arsenical Palmar Keratosis

Inclusion Criteria: * Age: 18-60 years * Palmar arsenical keratosis * Drinking arsenic contaminated water (\>50 µg/L) for more than six months * Patient voluntarily agree to participate Exclusion Criteria: * Pregnancy and lactating mother * Skin lesion :Psoriasis and eczema * Bowen's disease * Any kind of systemic disease, inflammatory disease and infectious condition that affect skin (Diabetes mellitus, Rheumatoid arthritis, Systemic lupus erythematosus , Hepatitis and Tuberculosis) * Hypersensitivity to any drug * Patient who received treatment within last three months