Changes in Ischemia and Angina Over 1 Year Among ISCHEMIA Trial Screen Failures With no Obstructive CAD on Coronary CT Angiography

Inclusion Criteria: * Enrolled but not randomized in ISCHEMIA trial * Stress echocardiography used for enrollment\* * No obstructive CAD on study coronary CT angiography (defined as no ≥50% stenosis in a major epicardial vessel) * Ischemic symptoms (chest pain or other potential ischemic equivalent). * Participant is willing to give written informed consent * Age ≥ 21 years Exclusion Criteria: * Inability to comply with protocol * Prior PCI or CABG