Phenylbutyrate in Proteinuric Nephropathies (NCT02343094) | Clinical Trial Compass
CompletedPhase 2/3
Phenylbutyrate in Proteinuric Nephropathies
France26 participantsStarted 2015-02
Plain-language summary
The purpose of this study is to determine whether sodium phenylbutyrate can reduce Lcn2 urinary expression in proteinuric patients.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Chronic Kidney disease for ore than 3 months
* Proteinuria \> 1g/d or 0,1g/mmmol creatinine
* eGFR \>30ml/mn/1,73m2
* written informed consent
* affiliated with social security health insurance
Exclusion Criteria:
* Women with childbearing potential
* Recent (\<3 months) modification of ACE inhibitors or ARB
* Acute renal failure
* eGFR \<30ml/mn/1,73m2
* Nephrotic syndrome (albuminélia \<30g/l)
* Infection with HIV, HCV, HBV
* Liver insufficiency
* No affiliated with social security health insurance
* inclusion in another protocol of biomedical research
* risk of non-adherence to protocol and visits
* patients having a cardiac insufficiency of grade 3 or 4
* patient requiring of a strict salt-free diet
* patients under corticoids or immunosuppresseurs
* clinical intolerance in the treatment
* intolerance in the fructose, the syndrome of malabsorption glucose and galactose or a deficit in sucrase / isomaltase
* patients treated by Probenecide
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.