Defective FGFR2 Signaling in the Small Airway Basal Progenitor Cells in COPD

Samples from newly recruited research subjects will be collected under the IRB approved protocol "Collection of Airway, Blood and/or Urine Specimens from Subjects for Research Studies" (IRB # 1204012331) or may have been collected under previous IRB approved collection protocols: #0005004439, #0005004440, and #0905010391. Inclusion Criteria: * Must be capable of providing informed consent * Males and females, age 18 or older * Nonsmoking, matched with other groups by age, sex, ethnic/racial group * Good overall health without history of chronic lung disease, including asthma, and without recurrent or recent (within 3 months) acute pulmonary disease * Normal physical examination * Normal routine laboratory evaluation, including general hematologic studies, general serologic/ immunologic studies, general biochemical analyses, and urine analysis * Negative HIV serology * Normal chest X-ray (PA and lateral) * Normal electrocardiogram * Females - not pregnant * No history of allergies to medications to be used in the bronchoscopy procedure * Not taking any medications relevant to lung disease or having an effect on the airway epithelium * Willingness to participate in the study Exclusion Criteria: * Unable to meet the inclusion criteria * Pregnancy * Current active infection or acute illness of any kind * Current alcohol or drug abuse * Evidence of malignancy within the past 5 years