Non Invasive Prenatal Testing (NIPT) of Single-gene Disorders

Inclusion Criteria: * the pregnant woman is scheduled for or has recently undergone invasive prenatal testing (regular care) because of one of the following reasons: * the fetus is at high risk of a having inherited a single-gene disorder from his/her affected parent(s). * the fetus is at risk of having a de dominant novo disorder on the basis of ultrasonography findings. * the pregnant woman is 18 years or older * the pregnant woman has sufficient understanding of Dutch language and is able to give informed consent Exclusion Criteria: * if in the opinion of the treating physician psychological distress is so severe that asking for participation is not safe * the pregnant woman is treated for a malignancy