By InvitationNot Applicable

Phenotype, Genotype & Biomarkers in ALS and Related Disorders

United States700 participantsStarted 2015-04

Plain-language summary

The goals of this study are: (1) to better understand the relationship between the phenotype and genotype of amyotrophic lateral sclerosis (ALS) and related diseases, including primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA), and frontotemporal dementia (FTD); and (2) to develop biomarkers that might be useful in aiding therapy development for this group of disorders.

Who can participate

SexALL

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Inclusion criteria

✓. Individuals with a clinical diagnosis of ALS or a related disorder, including FTD, HSP, PLS, PMA and MSP (sporadic or familial).
✓. Family member of an enrolled affected individual.

What they're measuring

Phenotypic correlates of genotype

Timeframe: 24 months

Genetic determinants of phenotype

Timeframe: 24 months

Trial details

NCT IDNCT02327845

SponsorUniversity of Miami

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-07

View on ClinicalTrials.gov More Amyotrophic Lateral Sclerosis trials