CompletedNot Applicable

Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield

Netherlands807 participantsStarted 2015-01

Plain-language summary

Standard diagnostic work-up for adrenal incidentalomas (AI) consists of periodical biochemical analysis and CT-scanning in case the initial work-up does not demonstrate the presence of hormonal hypersecretion or adrenocortical carcinoma (ACC), respectively. The overall aim of this study is to improve the cost-effectiveness of the diagnostic strategy for AI. Cost-effectiveness of urine steroid profiling (USP) will be compared to the standard diagnostic strategy of repeated CT-imaging.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * discrete adrenal mass \> 1 cm in diameter incidentally discovered during CT/MRI-scanning, performed for reasons other than an evaluation for adrenal disease * detection CT/MRI-scan performed ≤ 4 months ago * age 18 years or older. Exclusion Criteria: * extra-adrenal malignancy (i.e. active or past medical history of malignancy, except for basal cell carcinoma) * radiologic diagnosis of simple cyst or bilateral adrenal masses * allergy to radiocontrast * renal insufficiency (i.e. eGFR \< 30 ml/min/1.73m2) * pregnancy * adrenal incidentaloma visible on previous (i.e. \> 4 months ago) CT/MRI-scan * inability to understand written Dutch.

What they're measuring

Cost-effectiveness

Timeframe: 2 years

Trial details

NCT IDNCT02324647

SponsorUniversity Medical Center Groningen

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-06

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