Cancer Genetics Hereditary Cancer Panel Testing (NCT02324062) | Clinical Trial Compass
CompletedNot Applicable
Cancer Genetics Hereditary Cancer Panel Testing
United States1,511 participantsStarted 2014-06-12
Plain-language summary
This study is about understanding the use of a genetic test (Myriad Genetics myRisk panel) that analyzes 25 genes related to different hereditary cancer conditions. The investigators hope to learn more about how this type of genetic test is used clinically. The investigators also hope to understand more about the experience of individuals and families who undergoing this test of genetic testing.
Who can participate
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:Screening Criteria Patients meeting one of the following criteria will be eligible for screening the study.
* Any individual with multiple primary cancers
* Any individual diagnosed with cancer under age 50
* Individuals with two or more first or second-degree relatives with cancer.
* Individuals from families where at least one family member was diagnosed with cancer under age 50
* Individuals meeting a phenotypic diagnosis of specific hereditary cancer syndromes including, but not limited to:
* Hereditary Breast and Ovarian Cancer
* Lynch Syndrome
* Familial or Attenuated Adenomatous Polyposis Syndrome
* Hereditary Melanoma Syndrome
* Hereditary Pancreatic Syndrome
* Li Fraumeni Syndrome
* Cowden Syndrome
* Hereditary Diffuse Gastric Cancer
* Peutz Jeghers Syndrome
* Juvenile Polyposis Syndrome
* Ataxia Telangiectasia (Louis-Bar syndrome)
Individuals with a pretest mutation probability of \> 2.5% based on validated published models 15
* Mismatch Repair (MMR)pro
* Prediction model for mutL homolog 1 (MLH1), muS homolg 2 (MSH2), and mutS homolog 6 (MSH6) gene mutations (Premm 1,2,6)
* Pancreas (Panc)Pro
* Melanoma (Mela)Pro
* Breast cancer (BRCA)Pro
* Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA)
* International Breast Cancer Intervention Study (IBIS) (Tyler-Cuzick)
* Myriad II
* Phosphatase and tensin homolog (PTEN) Cleveland Clinic Score
* Clinical probability of \> 2.5% where models…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.