Early Salpingectomy (Tubectomy) With Delayed Oophorectomy in BRCA1/2 Gene Mutation Carriers

Inclusion Criteria: * Premenopausal women with a documented BRCA1 and/or BRCA2 germline mutation * Age 25-40 years for BRCA1 mutation carriers, 25-45 years for BRCA2 * Childbearing completed * Presence of at least one fallopian tube * Participants may have a personal history of non-ovarian malignancy Exclusion Criteria: * Postmenopausal status (natural menopause or due to (cancer) treatment) * Wish for second stage oophorectomy within two years after salpingectomy (if clear at enrollment) * Legally incapable * Prior bilateral salpingectomy * A personal history of ovarian, fallopian tube or peritoneal cancer * Evidence of malignant disease at enrollment * Treatment for malignant disease at enrollment * Inability to read or speak Dutch BRCA mutation carriers who opt for salpingectomy but who do not want to postpone the oophorectomy beyond the guideline age will undergo similar follow-up but do not contribute to the 510 inclusions we need