Stopped: Interim analysis confirmed too high rate of bone flap resorption. Continuation of the study was deemed unethical. Available data allow evaluation with sufficient power.
The complications after reimplantation of cryoconserved autologous bone flaps are reported inhomogeniously in the literature. Especially the incidence of bone flap resorption varies from 0% to about 30%. More recent retrospective studies seem to find higher resorption rates and thus suggest to implant artificial bone replacements from the start. The Swiss Prospective Autologous bone Resorption Study is the first propspective observational study designed to determine the true incidence of autologous bone resorption.
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Incidence of a relevant bone resorption within 12 months after reimplantation
Timeframe: 12 months