Blood-flow Restricted Exercise in Inclusion Body Myositis

Inclusion Criteria: Clinical features * Duration of weakness \> 12 months * Weakness of finger flexors \> shoulder abductors AND knee extension \> hip flexion Pathologic features * Invasion of nonnecrotic fibres of mononuclear cells or rimmed vacuoles or * increased major histocompatibility complex I (MHC-1) but no intracellular amyloid deposits or 15-18nm filaments Exclusion Criteria: * Lack of gait function * Co-morbidity contraindicating the use of blood-flow restricted training (previous deep vein thrombosis/pulmonary embolism or known peripheral ischemic disease). * Co-morbidity preventing resistance training (severe heart/lung-disease, uncontrolled hypertension (systolic \> 160mmHg, diastolic \> 100mmHg), severe knee/hip arthritis)