Impact of a Surgical Sealing Patch on Lymphatic Drainage After ALND for Breast Cancer

Inclusion Criteria: at registration * Patient has given written informed consent before registration * Female patients; eligible for primary ALND or sentinel lymph node procedure with frozen section and either: * newly diagnosed * or recurrent breast cancer in the conserved breast, chest wall or axilla * Patients with histo- or cytology proven breast cancer UICC/AJCC stage I-III * Age ≥ 18 years * Fluency in either German, French, Italian, Spanish, Turkish or English * The EQ-5D questionnaire has been completed at registration * Patient with child-bearing potential, willing to use effective contraception, not currently pregnant and agreeing not to become pregnant after trial registration and during the 24 weeks after surgery * A negative pregnancy test within 14 days prior to inclusion is available for all women with child-bearing potential Inclusion criteria at randomization \- ALND indicated according to clinical standards, either as single procedure or in combination with breast conserving surgery Exclusion Criteria at registration: * Known hypersensitivity for TachoSil® or fibrin sealant * Patients with mastectomy (simultaneously or within 1 month before registration); patients undergoing completion mastectomy at a later day will remain eligible and are evaluable for analysis according to intention to treat. If the axillary drain is still in place at the time of completion mastectomy and a separate drain is inserted underneath the skin flaps, only the axillary drain…