A Phase Ⅲ Clinical Trial With Oral Recombinant Helicobacter Pylori Vaccine in Chinese Children

Inclusion Criteria: * Healthy children aged from 6-15 years old as established by medical history and clinical examination * The subjects' guardians are able to understand and sign the informed consent * Subjects who can and will comply with the requirements of the protocol * Subjects with temperature \<=37.0°C on axillary setting before vaccination Exclusion Criteria: Exclusion criteria for the first dose * Subject who has a medical history of stomach illness * Positive in either serology ELISA test for Helicobacter pylori diagnose kit or 13C urea breath test * Subject who has suffered from heart, liver, and kidney disease * Subject who has a medical history of any of the following: allergic history, or allergic to any ingredient of vaccine (for example: mannitol) * Subject who is suffering from thrombocytopenia or other coagulation disorder * Subject who has a diminished function of the immune system or autoimmune disease * Subject who is suffering from congenital deformities, developmental disorders or serious chronic diseases * Family history of seizures or progressive neurological disease * Severe malnutrition or dysgenopathy, major congenital defects or serious chronic illness, including perinatal brain damage * Any acute infections in last 7 days * Any prior administration of immunodepressant or corticosteroids in last 6 month * Any prior administration of other research medicines in last 1 month * Any condition that in the opinion of the investigator, may interfer…