The goal of this application is to determine whether changing the timing of food intake prevents the adverse metabolic effects of circadian misalignment.
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Change in plasma leptin levels across sleep/wake cycle
Timeframe: During circadian alignment (Day 7) and circadian misalignment (Day 10-11)
Change in circadian profile of plasma leptin
Timeframe: During constant routine before forced desynchrony (Days 3-4) and constant routine after forced desynchrony (Days 12-13)
Change in glucose tolerance
Timeframe: During circadian alignment (Day 7) and circadian misalignment (Day 10-11)
Change in circadian profile of plasma glucose levels
Timeframe: During circadian alignment (Day 7) and circadian misalignment (Day 10-11)
Change in plasma insulin levels after standardized test meal
Timeframe: During circadian alignment (Day 7) and circadian misalignment (Day 10-11)
Change in circadian profile of plasma insulin levels
Timeframe: During circadian alignment (Day 7) and circadian misalignment (Day 10-11)