UnknownNot Applicable

Genetic and Morphological Analysis of Thyrotoxic Periodic Paralysis

160 participantsStarted 2014-10

Plain-language summary

The study aims to analyze the genetic variance between thyrotoxic periodic paralysis (TPP) patients and pure hyperthyroidism individuals. Meanwhile, the investigators also intended to evaluate the morphological difference in effected skeletal muscles and investigate their relation with genetic variance.

Who can participate

Age range20 Years – 60 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: A recent history(within three months) of acute limb muscle weakness, hypokalemia and decreased TSH with elevated free FT4, FT3. Exclusion Criteria: Hyperthyroid myopathy with long term muscle weakness, family periodic paralysis, renal tubular acidosis, hyperaldosteronism, hemiplegia, paraplegia, or any history of other metabolic or traumatic muscular disease,

What they're measuring

Single Nucleotide Polymorphisms

Timeframe: 2 years

skeletal muscle size of biceps brachii and quadriceps femoris

Timeframe: 2 years

Trial details

NCT IDNCT02287363

SponsorWest China Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2016-10

View on ClinicalTrials.gov More Thyrotoxic Periodic Paralysis trials