Microdrilling Surgery for Full Thickness Chondral Lesions of the Knee Augmented With Concentrated Bone Marrow Aspirate, Platelet Rich Plasma and Hyaluronic Acid

Inclusion Criteria: MRI-confirmed full-thickness unipolar or bipolar chondral lesion(s) from osteoarthritis. Exclusion Criteria: * Inflammatory arthritis * Body mass index (BMI) greater than 35 * Presence of significant varus or valgus knee instability or unusually stiff knee * Greater than 50% deviation of the mechanical axis * Presence of active cardiac disease * Presence of active pulmonary disease * Prior septic arthritis of the involved joint * Presence of active bacterial or Mycobacterial infection * Presence of a known hypercoagulable state * Pregnant or lactating females * Subject known to be positive for hepatitis B, hepatitis C, or HIV * Known allergy to hyaluronic acid * Patients who are unable or unwilling to participate fully in post-operative physical therapy * Patients with a contraindication to MRI scanning * Any disorder that compromises ability to give consent or comply with study procedures * Patients who are felt to be at significantly increased risk for elective orthopedic surgery * Non-ambulatory patients * Patients with cognitive impairment