CompletedPhase 2

Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana

Ghana200 participantsStarted 2014-10

Plain-language summary

This study will determine the influence of doxycycline treatment against Wolbachia/M. perstans on immunity against concomitant mycobacterial infections in healthy M. perstans infected individuals. In this regard, the investigators will perform a community-based randomized controlled trial (Phase 2a) in Asante Akim North District. A cohort of 200 participants who are contacts of patients with Tuberculosis or Buruli ulcer, of both sexes with no clinical condition requiring long-term medication but connected with Mansonella perstans will be investigated for the effect of doxycycline on microfilaria, the immune response and development of mycobacterial disease.

Who can participate

Age range9 Years – 55 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: M. perstans mg-positive status Good general health without any clinical condition requiring long-term medication. Normal renal and hepatic laboratory profiles Exclusion Criteria: Known intolerance to the doxycycline Body weight \<40 kg Pregnancy or breastfeeding History of severe allergic reaction or anaphylaxis Alcohol or drug abuse

What they're measuring

Microfilarial assessment

Timeframe: Change from baseline microfilarial load at 12 months

Trial details

NCT IDNCT02281643

SponsorKwame Nkrumah University of Science and Technology

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-03-15

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