World-wide Randomized Antibiotic Envelope Infection Prevention Trial

Inclusion Criteria: * Patient is willing to sign and date the study patient informed consent (PIC) form * Patient is at least 18 years of age and meets age requirements per local law * Patient is planned to undergo at least one of the following: a. Patient has existing cardiac implantable electronic device (CIED) and is undergoing implantable pulse generator (IPG) (including cardiac resynchronization therapy pacemaker \[CRT-P\]), implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT-D) replacement or upgrade with a new Medtronic generator i. Subjects planned to have leads added, or extracted and added for upgrades can be enrolled OR b. Patient will undergo a de novo Medtronic CRT-D system implant per approved indications OR c. Patient has existing study eligible Medtronic CIED in which the pocket was not accessed within the last 365 days, and is undergoing pocket or lead revision * Willing to provide the contact information for the physician who provides followup for his/her CIED * Willing and able to comply with scheduled follow-up and study related activities Exclusion Criteria: * Known allergy to minocycline or rifampin or their derivatives, or any other known contraindications to implantation of the TYRX envelope. * Current therapy with chronic oral immunosuppressive agents or ≥ 20mg/day of Prednisone or equivalent. * Hemodialysis or peritoneal dialysis. * Prior Cardiac transplantation or existing Ventricular A…