Study on Analgesia of GIC-1001 & GIC-1002 on Visceral Pain, Rectal Sensory Threshold Using the Barostat Method

Inclusion Criteria: * Male or female volunteer * A female volunteer must meet one of the following criteria: Participant is of childbearing potential and agrees to use one of the accepted contraceptive regimens from at least 28 days prior to the first dosing, during the study and for at least 30 days after the last dosing or participant is of non-childbearing potential, i.e. surgically sterile or menopausal (at least 1 year without menses) * Age between 18 to 65 years * 35.00 kg/m2 ≥ Body Mass Index ≤ 18.50 kg/m2 * Light-, non- or ex-smokers. A light smoker is smoking 2 cigarettes or less per day for at least 3 months before Day 1. An ex-smoker is someone who completely stopped smoking for at least 6 months before Day 1 * Barostat naive or no barostat experience in the year preceding screening * Clinical laboratory values within the laboratory's stated normal range; or without any clinical significance * Have no history of clinically significant diseases or evidence of clinically significant findings on physical exam and/or clinical laboratory tests * Have a normal anorectal area, confirmed by entry digital rectal exam (DRE) and * Signed dated informed consent form by subject Exclusion Criteria: * Pregnant or lactating females * History of significant hypersensitivity to trimebutine, to sulfur-containing drugs or any related products (including excipients of the formulations) as well as severe hypersensitivity reactions (like angioedema) to any drugs * Presence of signif…