CompletedNot Applicable

Trajectory of Recovery in the Elderly

United States104 participantsStarted 2015-07

Plain-language summary

The purpose of this study is to understand how elderly individuals regain their cognitive skills following general anesthesia. The investigators will compare an age stratified group of volunteers who will be evaluated with a series of cognitive tests and a functional MRI. The participants will then be administered general anesthesia for two hours. The investigators will then assess the participants using state of the art tools to determine when participants return to their cognitive baseline.

Who can participate

Age range40 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 40-80 years old * American Society of Anesthesiologists (ASA) Physical Status I or II (i.e. Individuals with minimal disease burden) * Capable and willing to consent Exclusion Criteria: * Airway assessment as potentially difficult (Mallampati III or greater) * Allergies or hypersensitivity to drug or class * Chronic Inflammatory conditions such a lupus or system rheumatoid arthritis (arthritis limited to 1 or 2 joints will be acceptable) * Patients with diabetes mellitus * Patients with a recent illness (within the last 2 weeks) * Patients with severe visual or auditory disorder/handicaps * English illiteracy * Pregnancy * Participants not expected to be able to complete the postoperative tests * History of malignant hyperthermia * Nursing mothers * Body Mass Index \> 30 * Patients with significant metal implants in body * Current use of cocaine or opiates * Current smokers

What they're measuring

Number of Participants Recovered on Postoperative Quality of Recovery Scale (PQRS)

Timeframe: 15 min, 60 min, 1 day, 3 days, 7 days, 30 days, 6 months

Trial details

NCT IDNCT02275026

SponsorIcahn School of Medicine at Mount Sinai

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-04-22

Results submitted2021-04-27