A Clinical and Imaging Study to Evaluate a Novel Dentifrice

Inclusion Criteria: * Male or female over the age of 18 * Have a previously diagnosed condition of gingivitis and periodontitis including gingival bleeding, gingival inflammation, plaque, and for some study sections at least four sites with probing pocket depths \> 4mm. * Not pregnant and not lactating. Exclusion Criteria: * Participated in other clinical study within the last 30 days. * Plan to receive dental treatment during the study dates. * History of significant adverse effects following use of oral hygiene products such as toothpastes and mouth rinses. * Allergies to personal care/consumer products or their ingredients. * Less than 20 teeth (excluding third molars). * For some studies, within six months prior to baseline, any quadrant or maintenance S/RP, and/or periodontal surgical therapy * Diagnosed with active acquired immunodeficiency syndrome (AIDS) or Hepatitis B/C and other significant disease or disorder. * Poorly controlled diabetes * History of herpetic infection, recurrent aphthous ulcer, or other ulcerative diseases, abscesses, granulomas. * History of or currently undergoing immunosuppression * Taken antibiotics in the previous 3 months. * Taking anti-inflammatory medications or Immunosuppressants.