CompletedNot Applicable

Morbidity in Patients With Hypertension and Obstructive Sleep Apnea

Brazil123 participantsStarted 2015-01

Plain-language summary

MORPHEOS is a multicenter, randomized, unblinded study, for patients diagnosed with uncontrolled hypertension and at least one antihypertensive medication. Those patients with significant sleep apnea wil be randomized to CPAP or nasal strips for 6 months.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥ 90 mm Hg * Current treatment with at least 1 antihypertensive drug Exclusion Criteria: * Age \<18 and \>65 years * BMI ≥ 40 kg/m2 * Heart failure, EF \< 45%, acute myocardial infarction, stroke, significant valvular dysfunction * Chronic renal failure (serum creatinine \> 2 mg/dL) * Use of cocaine, amphetamines, alcohol, illicit drugs * Use of sympathomimetics (decongestants, appetite suppressants) * Use of oral contraceptives and chronic use of NSAIDs * Pregnancy * Secondary causes of hypertension (other than sleep apnea)

What they're measuring

Impact of OSA treatment with CPAP on office, 24-hour, and central blood pressure (co-primary endpoints).

Timeframe: 6 months

Trial details

NCT IDNCT02270658

SponsorUniversity of Sao Paulo General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-01

View on ClinicalTrials.gov More Hypertension trials