Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin

Inclusion Criteria: * Veterans or active duty service members aged 18 or older of either gender * Good general health * History of blast and/or impact head/neck trauma meeting DVBIC criteria for mild TBI, i.e., injury as manifested by at least one of the following: * 1\) any period of loss of consciousness * 2\) any loss of memory for events immediately before or after the accident * 3\) any alteration in mental status at the time of the accident (e.g., feeling dazed, disoriented, or confused) * 4\) focal neurological deficit(s) that may or may not be transient, with severity of injury not exceeding loss of consciousness 30 minutes, Glasgow Coma Scale \<13-15 after 30 minutes, or posttraumatic amnesia \>24 hrs, * Headaches that started within 3 months of a head/neck injury or pre-existing headaches that markedly worsened (by a two-fold or greater increase in frequency and/or severity) within 3 months of a head/neck injury. Headaches must either 1) last 4 or more hours a day and reach a moderate to severe intensity at any point during the headache or 2) may be of any severity or duration if the participant uses a medication or other agent in an effort to stop the headache. Headaches meeting these criteria must have been present on average at least 8 days per 4-week period over the 3 months preceding study enrollment. * Comorbid PTSD or other anxiety disorder is not exclusionary. * Fluency in English is required. * Persons of all races and ethnicities are eligible. * …