UnknownPhase 1/2

Effects of Transcranial Direct Current Stimulation Associated With Physical Exercise: a Metaplasticity Study

Brazil12 participantsStarted 2014-02

Plain-language summary

This study aims to understand metaplasticity through the association of transcranial direct current stimulation (tDCS) and physical exercise. For this purpose, the study will be separate in 2 phases: in the first phase the aim is verify the effects of physical exercise on cortical excitability. After this 1st phase two intensities of physical exercise will be chosen for the second phase. In the 2nd phase, subjects will undergo to anodal, cathodal and sham tDCS plus physical exercise.

Who can participate

Age range

18 Years – 45 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Self reported healthy * Right handed Exclusion Criteria: * Prior neurological diseases * Multiple brain lesions * Metal implant in the skull and face * Pacemaker * History of seizures * Epilepsy * Pregnancy * Hemodynamic instability * Use of medications which change the cortical excitability, such as antidepressants, anxiolytics. * Energy expenditure \> 3000 METS

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change on cortical excitability - motor evoked potential (MEP)

Timeframe: Phase 1 - in each session (every day), baseline and every 5 minutes for 30 minutes after exercise/rest. Phase 2 - in each session (every day), baseline, after, 10, 20, 30, 60 and 90 after tDCS + exercise

Trial details

NCT IDNCT02263092

SponsorUniversidade Federal de Pernambuco

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-02

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