Examination of the Pathophysiologic Mechanisms of CRPS by Using QST, CPM, RIC, and Heart Rate Var… (NCT02261012) | Clinical Trial Compass
CompletedNot Applicable
Examination of the Pathophysiologic Mechanisms of CRPS by Using QST, CPM, RIC, and Heart Rate Variability QST
Germany62 participantsStarted 2014-04
Plain-language summary
This study aims for a better understanding of the pathophysiological mechanisms of the complex regional pain syndrome (CRPS). This will be done by testing the quantitative sensory testing, the remote ischemic conditioning, the conditioned pain modulation (CPM) and the analysis of the heart-rate variability in patients with CRPS and a control-group. We hypothesize decreased conditioned pain modulation, less effects of remote ischemic conditioning and an affection of the heart-rate variability in patients with CPRS.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
CRPS-patients
Inclusion Criteria:
* Unilateral pain on the upper limbs, based on a scintigraphic ensured CRPS (average pain in the last 4 weeks ≥ 3 in pain Detect)
* Pain history \< 1 year
Exclusion criteria:
* Bilateral pain on the upper limbs
* Inadequate knowledge of the german language in speaking and writing
* Acute psychiatric sickness
* Polyneuropathy
* Any added neuropathic sickness on the not affected upper limb sight
* Intolerable pain during the testing
* Injuries within the tested areal
* Acute injuries on the hand
* Pregnancy
* Missing informed consent
CTS-patients
Inclusion Criteria:
* Unilateral pain on the upper limbs, based on a scintigraphic ensured CRPS (average pain in the last 4 weeks ≥ 3 in pain Detect)
* Pain history \< 1 year
Exclusion criteria:
* Bilateral pain on the upper limbs
* Inadequate knowledge of the german language in speaking and writing
* Acute psychiatric sickness
* Polyneuropathy
* Any added neuropathic sickness on the not affected upper limb sight
* Intolerable pain during the testing
* Injuries within the tested areal
* Acute injuries on the hand
* Pregnancy
* Missing informed consent
Healthy subjects
Inclusion Criteria:
* Age \> 18 years
* Written consent
Exclusion criteria:
* Inadequate knowledge of the german language in speaking and writing
* Current pain
* Pain within in the last 14 days
* Any serious internistic medicin
* Any chronic skin disease
* Any central neural sickness
* Polyneuropathy
* Peripheral nerve lesi…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.