CompletedPhase 4

Warfarin Prevents Portal Vein Thrombosis in Patients After Laparoscopic Splenectomy and Azygoportal Disconnection

China124 participantsStarted 2014-09

Plain-language summary

The purpose of this study is to determine whether Warfarin Anticoagulation are effective and safe in Prevention of Portal Vein Thrombosis in Liver Cirrhotic Patients after Laparoscopic Splenectomy and Azygoportal Disconnection for Portal Hypertension

Who can participate

Age range18 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * A clinical, radiological or histologic diagnosis of cirrhosis of any etiology * Splenomegaly with secondary hypersplenism * Bleeding portal hypertension * INo evidence of PVT or spleno-mesenteric thrombosis by ultrasound evaluation and angio-CT * Informed consent to participate in the study Exclusion Criteria: * Hepatocellular carcinoma or any other malignancy * Hypercoagulable state other than the liver disease related * DRUGS- oral contraceptives, anticoagulation or anti-platelet drugs * Base line INR \>2 * Child-Pugh grade C * Recent peptic ulcer disease * History of Hemorrhagic stroke * Pregnancy * Uncontrolled Hypertension * Age\>75 yrs * Human immunodeficiency virus (HIV) infection

What they're measuring

Proportions of patients who will suffer PVT or spleno-mesenteric thrombosis between oral anticoagulant Warfarin with dipyridamole group and oral Aspirin with dipyridamole group during the study period of 3 year from randomization

Timeframe: 3 years

Trial details

NCT IDNCT02247414

SponsorYangzhou University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-09

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