Recurrent Urinary Tract Infections and Heparin (RUTIH Trial)

Inclusion Criteria: * Women aged 18-85 with history of recurrent urinary tract infections. * Definition of Recurrent UTI: if experienced either more than 3 symptomatic UTI episodes in the past year (including the index infection) or 2 such episodes in the past 6 months. * Definition of UTI: \>103 cfu/mL of a uropathogen in midstream urine culture from a woman experiencing more than 2 symptoms of cystitis (dysuria, urgency, frequency, suprapubic pain, or hematuria) or, in the absence of a culture, demonstration of pyuria on urinalysis and more than 2 urinary symptoms, as well as complete and rapid resolution of symptoms in response to antibiotic therapy for UTI. Exclusion Criteria: * Taking any anticoagulant such as warfarin sodium, heparin * Taking any thrombolytic agent such as a tissue plasminogen activator or streptokinase * Known aneurysm, thrombocytopenia, hemorrhagic disease, hemophilia, gastrointestinal ulceration, polyps, or diverticula * Known hypersensitivity to heparin * History of, or currently has neurogenic bladder, pelvic irradiation or chemical cystitis * Presence of urethral, pelvic, or rectal carcinoma, Benign or malignant bladder tumors * Tuberculous cystitis, urinary schistosomiasis * Bladder or ureteral calculi, urethral or bladder obstruction, augmentation cystoplasty, cystectomy, supratrigonal denervation of the bladder (cystolysis), neurectomy, or implanted peripheral nerve stimulator that has affected bladder function; Microscopic hematuria as…