Traditional Chinese Medicine Combined With Entecavir to Treat Refractory Liver Fibrosis in Liver Cirrhosis Due to HBV

Inclusion Criteria: * Hepatitis B history or more than 6 months history of positive HBsAg * Within 2 years of Entecavir treatment, HBV-DNA is negative but has not reach the clinical endpoint (HBeAg seroconversion or HBsAg loss in HBeAg-positive patients; HBsAg loss or anti-HBs seroconversion in HBeAg-negative patients) * Age 18-60 * Ishak fibrosis score of the biopsy within 6 months ≥5, no anti-fibrosis drug was taken within 6 months. * Child-Pugh\<7 (Stage A) * The patient or the patient's guardian agrees to participate the random controlled trial and sign the Informed Consent Form. Exclusion Criteria: * Decompensated liver cirrhosis * HCC * Liver histology conforming to other chronic liver diseases, such as moderate or severe non-alcoholic fatty liver disease(more than 1/3 steatosis in liver ), chronic hepatitis C, chronic hepatitis D, autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, inherited metabolic liver disease, drug or toxic induced liver injury, parasitic infections, alcoholic liver disease. * Have psychiatric history or uncontrollable epilepsy patient. * Uncontrollable diabetic patient * History of hemoglobin disease (such as alpha- or beta-thalassemia, sickle cell disease, spherocytosis) or patients with toxic or autoimmune hemolytic anemia. * Severe background disease like chronic respiratory failure, circulatory failure, kidney failure etc. * In situ organ transplantation (such as liver, kidney, lung and heart) or bone marrow…